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mleA [2017-8-11 16:0:3]
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mleA [2017-8-11 16:0:3]

malic enzyme
Locus
BSU23550
Isoelectric point
4.89
Molecular weight
45.73 kDa
Protein length
439 aa Sequence Blast
Gene length
1317 bp Sequence Blast
Function
malate utilization
Product
NAD-dependent malate dehydrogenase
Essential
no
E.C.
1.1.1.38
Synonyms
yqkJ
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of organic acids

    • Gene

    Coordinates
    2,451,463 → 2,452,782

    The protein

    Catalyzed reaction/ biological activity

  • (S)-malate + NAD+ = pyruvate + CO2 + NADH (according to Swiss-Prot) malate -→ pyruvate

    • Protein family

  • malic enzymes family (according to Swiss-Prot)

    • Paralogous protein(s)

  • YtsJ

    • Expression and Regulation

    Operons

    Genes
    mleN-mleA
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • AnsR: repression, PubMed, in AnsR regulon
  • CcpA: repression, PubMed, in CcpA regulon

    • Regulation

  • ansA: expressed in the presence of asparagine (AnsR) PubMed
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    Genes
    ansA-ansB-mleN-mleA
    Description
    PubMed

    Regulation

  • ansA: expressed in the presence of asparagine (AnsR) PubMed
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    Biological materials

    Mutant

  • MGNA-C412 (yqkJ::erm), available at the NBRP B. subtilis, Japan
  • GP1136 (cat) available in Stülke lab

    • References

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